Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. You can take tadalafil on its own or with a meal without affecting the amount of time it takes for the medication to start working. To learn more, read our blog on Adcirca vs. PDE5 inhibitors only work in the presence of nitric oxide, which is released during sexual arousal, so you will need to be aroused for Cialis to work. The first is that, because of the lower dosage, it often takes several days to become fully effective. · The 20mg dose can also be compounded at pharmacies and is generally cheaper but if you may obv have to consume/buy more pills for your dose. Cialis (20, 10, 5 and mg) takes about 90min for peak effect but this medication in the larger doses can last in the body for days. The lower doses of Cialis are known as the “daily” dosing and are . Here’s our process. How we vet brands and products Cialis (tadalafil) has FDA approval to treat erectile dysfunction (ED) and other sexual health conditions. This article features the most. Three Cialis mg to 5 mg subjects, three Cialis 5 mg subjects and two placebo subjects discontinued study participation due to an adverse event (AE). Nasal congestion was the only AE leading to discontinuation reported by more than one subject (two subjects in the tadalafil to 5 mg group).