Dapoxetine is not recommended in men with severe renal impairment, and caution is advised in men with mild to moderate renal impairment. The risk of adverse cardiovascular outcomes from syncope cardiac syncope and syncope from other causes is increased in patients with underlying structural cardiovascular disease e. Unchanged active substance was not detected in the urine. A careful appraisal of individual benefit risk of Priligy should be performed by the physician after the first four weeks of treatment or at least after 6 doses of treatment to determine whether continuing treatment with Priligy is appropriate. Concomitant administration of single or multiple doses of 30 mg or 60 mg Priligy to patients receiving daily doses of tamsulosin did not result in changes in the pharmacokinetics of tamsulosin. Each subject spontaneously recovered normal sinus rhythm. Subjects with other forms of sexual dysfunction, including erectile dysfunction and those using other forms of pharmacotherapy for the treatment of PE or antidepressants were excluded from all studies.Dapoxetine is a short-acting selective serotonin re-uptake inhibitor. Indications and dose. This medication is used to treat premature ejaculation. It increases time to ejaculate, and thus reduces the stress you face over how fast you ejaculate and may improve your satisfaction during sexual intercourse. Dapoxetine may increase the clearance of substrates of CYP1A and 2B6. PDE5 inhibitors. In a single dose crossover study, dapoxetine (60 mg) did not affect the pharmacokinetics of tadalafil (20 mg) or sildenafil ( mg). Warfarin and medicinal products that are known to affect coagulation and/or platelet function.