Then waiting until the level of arousal has diminished and starting again. Ans : Yes, Dapoxetine is safe to use only if consumed in dose and duration as prescribed by a healthcare professional. If you have ever had an allergic reaction to a medicine. An inherited eye disease that affects the retina. These drugs include: Modafinil Provigil.The dapoxetine/sildenafil combination therapy significantly improves the IELT values and patient reported outcome measures of PE patients who also . The dapoxetine/sildenafil combination therapy significantly improves the IELT values and patient reported outcome measures of PE patients who also suffer from ED. . This medication is taken with or without food an hour before sex. It works for up to 36 hours. You can take it in a small dose daily or in a larger dose as needed. .