In the meantime, consider exploring other ways in which you and your partner can connect. Behav Brain Res ; If you have a heart condition. Side effects might include nausea, headache, sleepiness and dizziness. Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation. The psychological burden of premature ejaculation. Efficacy and safety of dapoxetine for the treatment of premature ejaculation: integrated analysis of results from five phase 3 trials.When treating premature ejaculation, one of their side effects becomes useful: SSRIs also increase the time it takes until ejaculation occurs. Creams, gels or sprays that contain a . Dapoxetine is currently the oral drug of choice for on-demand treatment of PE. Keywords: Dapoxetine, premature ejaculation (PE), selective serotonin reuptake inhibitor (SSRI) . [88] Abu El-Hamd M, Abdelhamed A. Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with .