Soon, in , ICOS received a patent for compound IC structurally unlike sildenafil and vardenafil , and Phase 1 clinical trials began in People taking nitrates like nitroglycerin Nitrostat or isosorbide mononitrate Imdur should not take PDE5 inhibitors, as doing so could result in a dangerous drop in blood pressure. Erectile dysfunction can be caused by a variety of factors , including age, cardiovascular problems, diabetes, and other conditions that affect nerve function or blood flow. Most companies have an FAQ or shipping policy page you can reference to learn whether discreet packaging is available. In , the Phase 2 clinical studies were initiated for males experiencing ED, then progressed to the Phase 3 trials that supported the drug’s FDA approval. You should also call your insurance company to see if they cover erectile dysfunction medications. In , Pfizer scientists discovered that sildenafil, which also inhibits the PDE5 enzyme, caused penile erection in males participating in a clinical study of a heart medicine.Cialis comes in several strengths: milligrams (mg), 5mg, 10 mg, and 20 mg. The Cialis cost per pill and daily cost depend on several factors, such as: the strength prescribed by your doctor. heart attack symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating. Common tadalafil side effects may include: headache; flushing (warmth, redness, or tingly feeling); nausea, upset stomach; stuffy nose; or. muscle pain, back pain, pain in your arms, legs, or back. This is not a complete list of side. Tadalafil – STADA T20 – 20 Milligramm. Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. It is taken by mouth. Onset is typically within half an hour and the duration is up to 36 hours. Common side effects include headache, muscle pain, .