Those with a history of blood pressure or heart issues, hormonal imbalances, mental health issues, and diabetes should consult their doctor before trying PDE5 inhibitors. When oral medications might not be safe Check with your health care team before you take any medicine for erectile dysfunction. Common ones include: Flushing of the skin. Medicines that block an enzyme called CYP3A4. It’s available in 50 mg, mg, and mg tablets. However, all medications come with risks.The Savings Offer and Program expire on 12/31/ For further information, call , visit test1.ru, or write: Viatris Inc., P.O. Box , Mission, KS . Sildenafil (Viagra). Tadalafil (Cialis). Vardenafil. These medicines are called PDE5 inhibitors. They enhance the effects of a chemical the body makes that relaxes muscles . Vision changes. Muscle pain. But there are some differences. With Viagra, there is a higher risk of vision changes than with Cialis. Among people who take Viagra or sildenafil, 3% .