Vardenafil usually works for 4 to 5 hours. Generic versions of sildenafil, vardenafil and tadalafil are available. An inherited eye disease that affects the retina. Sildenafil is a drug that helps improve blood flow to the penis, allowing you to achieve a firm, longer-lasting erection more easily. As with sildenafil, a high-fat meal or alcohol keep the body from absorbing it as quickly.Some over-the-counter (OTC) supplements may help with erectile dysfunction, such as L-arginine in combination with pycnogenol, Korean red ginseng (also called panax ginseng), Yohimbe, Carnitine (propionyl-L-carnitine), and Dehydroepiandrosterone (DHEA). FAQs Takeaway We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission. Here’s our process. How we vet brands and products. General Health Fungal Infections Pain Aging Natural Medicine Men’s Health Penis ED Pills The 7 Best Over the Counter ED Medications August 23, Medically reviewed by David Culpepper, MD Erectile dysfunction is a frustrating, sensitive experience for any guy. Fortunately, there are several highly effective prescription treatment options.