You can also learn more about the causes of ED and the most effective methods of treatment in our full guide to erectile dysfunction. Does Viagra Expire? This means that you may not be able to safely use medications that can interact with sildenafil during this period. Therefore, the whole pill also expires eventually. By inhibiting this enzyme, blood flow is easier and this can result in firmer erections for those who have ED. Several different factors can affect how long Viagra remains active in your body, as well as its effectiveness as an ED treatment.It is usually two years after the indicated manufacturing date (2). That is its shelf life. However, it should be pointed out that this expiration date is only for the best . Like all medications, Viagra (Sildenafil) does expire. It has a shelf life of about 2 years. To ensure it lasts that long, you should store in a cool, dry area that’s not exposed to .  · Does Viagra Expire? Like most medications, Viagra can become less effective over time and expire if it’s left unused for too long. Take note of the expiration .