Enhancing Healthcare Team Outcomes Erectile dysfunction is mainly managed in the community setting with the help of primary care physicians, specialist nurses, pharmacists, and psychologists. Most patients with ED will not have an underlying psychological cause, but just having ED will damage relationships, increase stress, diminish self-esteem, and create anxiety; all of which interferes with a successful outcome. Have you already tried any treatments? Technically, there is no cure for ED. New relationships or medications? Online pharmacies such as GoodRx are also helping bring down the costs of erectile dysfunction medications. Left untreated, it can be the source of severe emotional stress to both patient and partner.Cost of erectile dysfunction pills. The cost to you for ED drug therapy varies considerably, depending on the pharmacy price, prescription co-pays, and your level of health plan . The four main medicines taken by mouth for erectile dysfunction are: Avanafil (Stendra). Sildenafil (Viagra). Tadalafil (Cialis). Vardenafil. These medicines are called PDE5 inhibitors. They enhance the effects of a chemical the body makes that relaxes muscles in the penis, called nitric oxide. It contains the same active ingredient as Levitra and can begin working in about 15 minutes. Viagra takes around 30 minutes to become effective and lasts about 4 hours. Cialis lasts much longer.