A newer form of the medicine that dissolves on the tongue might work faster than the pill that you swallow. Viagra affects the penis and other parts of the body. These include a heart attack, stroke or a serious heart rhythm disorder in the past six months. However, an excess of this will have most of the blood rushing toward the penis, which causes it to engorge and swell up. Men are likely to use the blue pills because sexual performance is a high priority for them, which can consequently lead them to abuse and overdoses. Less blue pills is more when it comes to healthy sexual function.Oral medicines for ED usually work well and cause few side effects. The four main medicines taken by mouth for erectile dysfunction are: Avanafil (Stendra). Sildenafil . Medically reviewed by Melissa Badowski, PharmD, MPH, FCCP — By Jennifer Mitri Williamson, Pharm.D. — Updated on September 12, Learn about .